Restylane is manufactured using NASHA technology, creating a particle size-differency and effect-lasting gel; Juvederm is manufactured using HYLACROSS technology, creating a smooth-consistency gel;
Godfiller is manufactured combining NASHA and HYLACROSS technology, creating a smooth-consistency and effect-lasting gel.

Godfiller cross-linked sodium hyaluronate gel for plastic surgery is a sterile, biodegradable, viscoelastic, isotonic, homogenized and transparent injectable gel implant. It is a kind of stable sodium hyaluronic acid of non-animal origin, intended for single use only.
This kind of cross-linked hyaluronic acid provides a prolonged half-life compared with naturally formed hyaluronic acid, which undertakes the physiological breakdown in subcutaneous tissues.
Native cross-linked HA contains larger and more stable molecules with similar biocompatibility and viscoelastic filling properties so that it has longer residue time in the tissues. Large molecular network structure of HA combines with large amount of water to form hydrogen bonds and constitute matrix in the body, which have the functions of regulating the osmotic pressure and macromolecules, forming a physical barrier and regulating the action of cell.
HA molecules have different physiological roles in different tissues, such as water conservation in skin; lubrication action in synovial fluid; main regulator of permeability in vessel wall.
In addition, as a kind of polyanion electrolyte, HA molecules have a large amount of negative charge, which can adjust the concentration of positive and negative ions around and control the activity of enzymes.